Absorption and bioavailability of oral erythromycin.
نویسندگان
چکیده
منابع مشابه
Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability
Most of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of administration (Lipinski 1995; Lipinski 2000; Lipinski et al. 2001; Lipinski 2004; Abrahamsson and Lennernas 2005). Thus, oral bioavailability is one of the key considerations for discovery and development of a new chemical entity (NCE). It is well recog...
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In vitro studies with N-acetylcysteine (NAC) solutions used for inhalation treatment have demonstrated inactivation of some antibiotics by NAC. Oral NAC treatment is increasingly common for long-term prophylaxis in chronic bronchitis. During exacerbations, treatment with oral antibiotics will often be given simultaneously. We assessed the effect of simultaneous oral administration of NAC on the...
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BACKGROUND Erythromycin is available as the free base, ethylsuccinate, estolate, stearate, gluceptate, and lactobionate derivatives. When given orally erythromycin and its derivatives except the estolate are inactivated to some extent by the gastric acid and poor absorption may result. OBJECTIVES To establish whether delayed release erythromycin tablets meet the bioequivalent requirement for ...
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iv CHAPTER 1 – THESIS ORGANIZATION AND LITERATURE REVIEW 1 Thesis Organization 1 Abstract 1 Background Entry and detection of antibiotics in the environment 2 Movement and transport of erythromycin in the environment 5 Effects of antibiotics on organisms 8 Potential for the development of bacterial resistance in the environment 10 Problem formulation and research objectives 10 References 12 Fig...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1981
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1981.tb01191.x